Aside from its sexual connotations, this incredible word can be used to describe many situations:

Greetings	"How the fuck are ya?"
Fraud	"I got fucked by the car dealer."
Resignation	"Oh, fuck it!"
Trouble	"I guess I'm fucked now."
Aggression	"Fuck YOU!"
Disgust	"Fuck me."
Confusion	"What the fuck.......?"
Difficulty	"I don't understand this fucking business!"
Despair	"Fucked again..."
Pleasure	"I fucking couldn't be happier."
Displeasure	"What the fuck is going on here?"
Lost	"Where the fuck are we."
Disbelief	"UNFUCKINGBELIEVABLE!"
Retaliation	"Up your fucking ass!"
Denial	"I didn't fucking do it."
Perplexity	"I know fuck all about it."
Apathy	"Who really gives a fuck, anyhow?"
Greetings	"How the fuck are ya?"
Suspicion	"Who the fuck are you?"
Panic	"Let's get the fuck out of here."
Directions	"Fuck off."
Disbelief	"How the fuck did you do that?"
Anatomical Description	"He's a fucking asshole."
Telling Time	"It's five fucking thirty."
Business	"How did I wind up with this fucking job?"
Maternal	"Motherfucker."
Political	"Fuck Dan Quayle!"

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It has also been used by many notable people throughout history:

"What the fuck was that?"	-Mayor of Hiroshima
"Where did all these fucking Indians come from?"	-Gen. George A. Custer
"Where the fuck is all this water coming from?"	-Edward J. Smith, Captain of the RMS Titanic
"Thats not a real fucking gun."	-John Lennon
"Who's gonna fucking find out?"	- Richard Nixon
"Heads are going to fucking roll."	- Anne Boleyn
"What fucking map?"	-Mark Thatcher
"Any fucking idiot could understand that."	-Albert Einstein
"It does so fucking look like her!"	-Picasso
"How the fuck did you work that out?"	-Pythagoras
"You want what on the fucking ceiling?"	-Michaelangelo
"Fuck a duck."	-Walt Disney
"Why?- Because its fucking there!"	-Edmund Hilary
"I don't suppose its gonna fucking rain?"	-Joan of Arc
"Scattered fucking showers my ass."	-Noah
"I need this parade like I need a fucking hole in my head."	- John F. Kennedy